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In a dystopian near-future Japan, a dog-flu virus spreads throughout the canine population. Though one scientist, Professor Watanabe, is close to finding a cure, the authoritarian mayor of Megasaki City, Kenji Kobayashi, signs a decree banishing all dogs to Trash Island. The first exile is Spots, who belonged to Atari Kobayashi, the orphaned nephew and ward of the mayor.